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However, terfenadine was discovered to be the prodrug of the active molecule, fexofenadine, which does not carry the same risks as the parent compound.Therefore, fexofenadine could be placed on the market as a safe replacement for the original drug.Second generation antihistamines are less likely to cause impairment of cognitive facilities or performance skills.

Type IB agents rely on metabolic enzymes, especially in hepatic cells, to bioactivate the prodrugs intracellularly to active drugs.

Both major types can be further categorized into subtypes, based on factors such as (Type I) whether the intracellular bioactivation location is also the site of therapeutic action, or (Type 2) whether or not bioactivation occurs in the gastrointestinal fluids or in the circulation system.

See Table 1 below for further subtype categorization.

Many herbal extracts historically used in medicine contain glycosides (sugar derivatives) of the active agent, which are hydrolyzed in the intestines to release the active and more bioavailable aglycone.

For example, salicin is a β-D-glucopyranoside that is cleaved by esterases to release salicylic acid.

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  1. LOW/NON-SEDATING ANTIHISTAMINES. Combination low or non-sedating antihistamine products containing pseudoephedrine shall be. Example Brand Names. Strength

  2. This page includes the following topics and synonyms Sedating Antihistamine, First Generation Antihistamine, Antihistamine, Chlorpheniramine, Bromopheniramine.

  3. What's the difference between sedating and nonsedating antihistamines? Learn more about differences between sedating and nonsedating antihistamines at.

  4. Symbio's Food Effects Index. Welcome to this site. The purpose of this index is to assist individuals who are interested in learning about the physiological and psychological effects of consumables on the human condition.

  5. Lexicon of alcohol and drug terms published by the World Health Organization. Spanish pdf, 1.86Mb; absolute alcohol Ethanol containing not more than 1% by mass of also alcohol.

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